Comments on: what are heparin binding proteins, its role in epididymis possible project related to biochemistry? http://theworldsbesthomepage.com/blog/9528/what-are-heparin-binding-proteins-its-role-in-epididymis-possible-project-related-to-biochemistry/ Fri, 21 Nov 2008 12:36:31 +0000 http://wordpress.org/?v=2.6.2 By: Roy G. Biv http://theworldsbesthomepage.com/blog/9528/what-are-heparin-binding-proteins-its-role-in-epididymis-possible-project-related-to-biochemistry/#comment-15061 Roy G. Biv Mon, 26 May 2008 22:33:08 +0000 http://theworldsbesthomepage.com/blog/9528/what-are-heparin-binding-proteins-its-role-in-epididymis-possible-project-related-to-biochemistry/#comment-15061 The BSP proteins exhibit multiple binding and functional properties. They bind to choline phospholipids of cauda epididymal spermatozoa at ejaculation [11, 12]. Also, these BSP proteins bind to sperm capacitation factors, namely, heparin [13] and high-density lipoproteins (HDL) [14]. Recently it has been shown that BSP proteins potentiate the capacitation of bovine epididymal sperm induced by heparin [15] and HDL [16]. The mechanism underlying the heparin-induced capacitation is unknown, but the binding of BSP proteins to the sperm membrane appears to increase the number of heparin-binding sites on the sperm surface [15–17]. Recent results suggest that the mechanism by which HDL and BSP proteins stimulate sperm capacitation involves cholesterol efflux [17]. taken from: The BSP proteins exhibit multiple binding and functional properties. They bind to choline phospholipids of cauda epididymal spermatozoa at ejaculation [11, 12]. Also, these BSP proteins bind to sperm capacitation factors, namely, heparin [13] and high-density lipoproteins (HDL) [14]. Recently it has been shown that BSP proteins potentiate the capacitation of bovine epididymal sperm induced by heparin [15] and HDL [16]. The mechanism underlying the heparin-induced capacitation is unknown, but the binding of BSP proteins to the sperm membrane appears to increase the number of heparin-binding sites on the sperm surface [15–17]. Recent results suggest that the mechanism by which HDL and BSP proteins stimulate sperm capacitation involves cholesterol efflux [17].

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